Manufacturing Process & Capacity

Different production processes have a great influence on the quality of the medium. From the perspective of powder production, the particle size and mixing uniformity of powder is very important. If the particle size of the powder is uneven, too many coarse particles or fine particles may lead to powder stratification during storage and transportation, which will also have a certain impact when the solution is dissolved. In addition, heat may be generated during the grinding process, which may cause powder performance changes or raw material failure, so low-temperature grinding can reduce this risk.

After research and selection of many powder grinding and mixing devices, BioEngine finally adopted the Cone Mixing/Pin Milling (CMPM) powder production technology. The product has high uniformity and concentrated particle size distribution. The product is not easy to stratify during storage and transportation, and the quality is stable. In addition, CMPM enables continuous low-temperature grinding to ensure that material characteristics do not change during the production process and that the risks of production are controllable.

The phase II production base of BioEngine has completed the construction of low-temperature CMPM process consistency amplification for the 1,000-liter level, 10,000-liter level, and 100,000-liter level, which ensures the stability and reliable quality of the culture media products. At the same time, it improves the development efficiency of the customer's pilot stage process (from 8 hours to 4 hours) and the process development capability for large-scale production.

  • Cone Mixing

    Cone Mixing

    Mix well in a shorter time;
    Low line speed, low shear, and virtually no heat generation.

  • Pin Milling

    Pin Milling

    Cryogenic grinding by gas cooling;
    Concentrated particle size distribution, no stratification;
    Continuous production, suitable for high-efficient mass production;
    No need for screening, no screen blocking.

Automatic and information-based cone mixing/pin milling powder production technology for stable and high-quality media production
  • uniformity uniformity uniformity uniformity

    Good product uniformity

    Uniform mixing of trace elements, with little variation between batches

  • Automatic Automatic

    Automatic

    Reduce human interference

  • Continuous Continuous Continuous

    Continuous production

    High production efficiency, suitable for mass production

  • Low-temperature Low-temperature

    Low-temperature control(≤10°C)

    Reduce the risk of thermal material inactivation

  • Inert gas Inert gas Inert gas

    Inert gas protection

    Prevent the oxidation and inactivation of reducing substances

  • Information Information Information

    Information system support

    Sole source of information, standardized implementation

Capacity

Annual capacity of 1300 tons (about 55 million liters) for GMP-grade powder culture media  

Annual capacity of 500,000 liters for GMP-grade liquid culture media

Production line Type Batch capacity Process Grade
P0 Powder 1kg Mechanical crushing Research
P1 Powder 26kg (eq. 1000 L) CMPM Research
P2 Powder 26kg (eq. 1000 L) Cone mixing/ air milling Research
P3 Powder 260kg (eq. 10,000 L) CMPM GMP
P4 Powder 2600kg (eq. 100,000 L) CMPM GMP
L1 Liquid 100L C+A manual canning Research
L2 Liquid 1000L B+A automatic canning GMP

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We have a professional technical team to provide high quality one-stop cell culture service from process development and optimization, medium formulation design to medium processing and manufacturing for all biopharmaceutical companies.

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Professional Cell Culture Solutions for Biopharmaceutical Development

Our expert scientific team delivers end-to-end cell culture services to support your biopharmaceutical production needs. We provide comprehensive solutions including:
- Process development & optimization
- Customized medium formulation design
- Scalable medium processing & GMP manufacturing

For technical inquiries or service requests, please submit your message through our [Quick Message] portal. Our specialists will respond within 24 business hours.

For urgent matters, please contact +86 137 5514 6322 directly